双相情感障碍
荟萃分析
氧化应激
医学
炎症
内科学
心理信息
病理生理学
临床心理学
梅德林
锂(药物)
生物
生物化学
作者
Klaus Munkholm,Ilari Jaakko Olavi Mäkinen,Katrine Maigaard,Klara Coello,Anne Katrine Pagsberg,Lars Vedel Kessing
标识
DOI:10.1016/j.neubiorev.2024.105766
摘要
Evidence suggests a role for low-grade inflammation and oxidative stress in the pathophysiology of bipolar disorder. We conducted a systematic review and meta-analysis of peripheral markers of inflammation and oxidative stress in children and adolescents under 20 years of age with bipolar disorder. We searched PubMed, Embase and psycINFO and performed random effects meta-analysis calculating standardized mean differences (SMD) of marker levels between patients with bipolar disorder and healthy control individuals. Ten studies comprising a total of 418 patients with bipolar disorder and 3017 healthy control individuals were included. The levels of C-Reactive Protein were higher in patients with bipolar disorder compared with healthy individuals (SMD 0.53; 95 %CI: 0.33-0.74; I
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