Bipolar Disorder as a Mitochondrial Disease

Relapse, recurrence, and psychosis are common features in bipolar disorder (BD), affecting all aspects of an individual’s life with repercussions for the overall economy. BD is further compounded by the lack of measurable biological markers because current diagnosis relies largely on subjectively documenting mood and behavior. Without a thorough understanding of the underlying target biology of BD, the diagnosis, management, prevention, and treatment of this debilitating condition will remain an unsolved challenge, inflicting continued substantial burden on health care costs.