组织病理学
唾液腺
病理
活检
舍格伦综合征
医学
全身性疾病
疾病
作者
John S. Greenspan,T. E. Daniels,Norman Talal,Robert A. Sylvester
标识
DOI:10.1016/0030-4220(74)90417-4
摘要
Labial salivary gland biopsy specimens from seventy-five patients evaluated for Sjögren's syndrome were examined histologically. Clinically severe cases of Sjögren's syndrome showed the most marked histologic change. Focus score was found to be the most useful histologic index of severity of the disease. Large numbers of plasma cells were found in small foci and mild cases. Plasma cells were decreased in proportion, compared to lymphocytes, in larger foci and severe cases. These observations are discussed in the light of possible mechanisms of tissue damage in this disease.
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