化学
对映选择合成
镍
光催化
芳基
烷基
催化作用
组合化学
可见光谱
光化学
有机化学
光催化
光电子学
物理
作者
Lei Guo,Mingbin Yuan,Yanyan Zhang,Sheng Wang,Shengqing Zhu,Osvaldo Gutiérrez,Lingling Chu
摘要
A visible-light-promoted photoredox/nickel protocol for the enantioselective three-component carboarylation of alkenes with tertiary and secondary alkyltrifluoroborates and aryl bromides is described. This redox-neutral protocol allows for facile and divergent access to a wide array of enantioenriched β-alkyl-α-arylated carbonyls, phosphonates, and sulfones in high yields and excellent enantioselectivities from readily available starting materials. We also report a modular and enantioselective synthesis of flurbiprofen analogs and piragliatin lead compound to demonstrate synthetic utility. Experimental and computational mechanistic studies were performed to gain insights into the mechanism and origin of chemo- and enantioselectivity.
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