肠道菌群
益生元
蛹虫草
生物
多糖
失调
人口
肥胖
代谢组学
冬虫夏草
食品科学
生物化学
内分泌学
医学
生物信息学
环境卫生
作者
Rui Huang,Zhenjun Zhu,Shujian Wu,Juan Wang,Mengfei Chen,Wei Liu,Aohuan Huang,Jumei Zhang,Qingping Wu,Yu Ding
标识
DOI:10.1016/j.foodres.2022.111197
摘要
Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive. This study aims to explore the potential mediators of the anti-obesity effects of CMP in high-fat diet (HFD)-fed mice using 16S rRNA sequencing and untargeted metabolomics analysis. The results showed that CMP supplementation in HFD-fed mice reduced body weight, fat accumulation, pro-inflammatory cytokine levels, and impaired glucose tolerance as well as gut barrier. Moreover, the CMP reversed the HFD-induced gut microbiota dysbiosis, as indicated by the elevated population of Alloprevotella, Parabacteroides, Butyricimonas, and Alistipes; and decreased population of Negativebacillus, in addition to altered levels of metabolites, such as brassicasterol and 4′-O-methylkanzonol W. Notably, CMP prevented obesity in association with the altered gut microbes and metabolites. These findings suggest that CMP may serve as a potential prebiotic agent to modulate specific gut microbes and related metabolites, which play a critical role in its preventing obesity-related diseases.
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