雷公藤
雷公藤甲素
医学
雷公藤
糖尿病肾病
药理学
氧化应激
中医药
雷公藤醇
传统医学
肾
细胞凋亡
化学
内科学
生物化学
病理
有机化学
糖苷
替代医学
作者
Peng Liu,Jing Zhang,Yun Wang,Zhengri Shen,Chen Wang,Dan‐Qian Chen,Xinping Qiu
标识
DOI:10.3389/fmed.2021.747922
摘要
Tripterygium wilfordii Hook. f . (TWHF) is a traditional Chinese herbal medicine and widely used to treat diabetic kidney disease in China. Emerging evidences have revealed its ability to attenuate diabetic nephropathy (DN). Tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol are predominantly active compounds isolated from TWHF. The effects and molecular mechanisms of TWHF and its active compounds have been investigated in recent years. Currently, it is becoming clearer that the effects of TWHF and its active compounds involve in anti-inflammation, anti-oxidative stress, anti-fibrosis, regulating autophagy, apoptosis, and protecting podocytes effect. This review presents an overview of the current findings related to the effects and mechanisms of TWHF and its active compounds in therapies of DN, thus providing a systematic understanding of the mechanisms and therapeutic targets by which TWHF and its active compounds affect cells and tissues in vitro and in vivo .
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