Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas

生物 灵长类动物 缺氧(环境) 适应(眼睛) 高海拔对人类的影响 动物 适应 进化生物学 生理学 遗传学 生态学 解剖 氧气 神经科学 有机化学 化学
作者
Kenneth L. Chiou,Mareike C. Janiak,India Schneider‐Crease,Sharmi Sen,Ferehiwot Ayele,Idrissa S. Chuma,Sascha Knauf,Alemayehu Lemma,Anthony V. Signore,Anthony D’Ippolito,Belayneh Abebe,Abebaw Azanaw Haile,Fanuel Kebede,Peter J. Fashing,Nga Nguyen,Colleen McCann,Marlys L. Houck,Jeffrey D. Wall,Andrew S. Burrell,Christina M. Bergey,Jeffrey Rogers,Jane E. Phillips‐Conroy,Clifford J. Jolly,Amanda Melin,Jay F. Storz,Amy Lu,Jacinta C. Beehner,Thore J. Bergman,Noah Snyder‐Mackler
出处
期刊:Nature Ecology and Evolution [Springer Nature]
卷期号:6 (5): 630-643 被引量:18
标识
DOI:10.1038/s41559-022-01703-4
摘要

Primates have adapted to numerous environments and lifestyles but very few species are native to high elevations. Here we investigated high-altitude adaptations in the gelada (Theropithecus gelada), a monkey endemic to the Ethiopian Plateau. We examined genome-wide variation in conjunction with measurements of haematological and morphological traits. Our new gelada reference genome is highly intact and assembled at chromosome-length levels. Unexpectedly, we identified a chromosomal polymorphism in geladas that could potentially contribute to reproductive barriers between populations. Compared with baboons at low altitude, we found that high-altitude geladas exhibit significantly expanded chest circumferences, potentially allowing for greater lung surface area for increased oxygen diffusion. We identified gelada-specific amino acid substitutions in the alpha-chain subunit of adult haemoglobin but found that gelada haemoglobin does not exhibit markedly altered oxygenation properties compared with lowland primates. We also found that geladas at high altitude do not exhibit elevated blood haemoglobin concentrations, in contrast to the normal acclimatization response to hypoxia in lowland primates. The absence of altitude-related polycythaemia suggests that geladas are able to sustain adequate tissue-oxygen delivery despite environmental hypoxia. Finally, we identified numerous genes and genomic regions exhibiting accelerated rates of evolution, as well as gene families exhibiting expansions in the gelada lineage, potentially reflecting altitude-related selection. Our findings lend insight into putative mechanisms of high-altitude adaptation while suggesting promising avenues for functional hypoxia research.
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