扁桃斑鸠菊
倍半萜
化学
立体化学
绝对构型
植物化学
圆二色性
消炎药
二维核磁共振波谱
生物化学
生物
传统医学
药理学
医学
作者
Xiangzhong Liu,Wenjing Tian,Mi Ζhou,Qiannan Xu,Yanqing Wu,Renjing Yang,Shoulun He,Guanghui Wang,Ting Lin,Haifeng Chen
出处
期刊:Phytochemistry
[Elsevier]
日期:2022-06-21
卷期号:201: 113283-113283
被引量:4
标识
DOI:10.1016/j.phytochem.2022.113283
摘要
The phytochemical assessment of Vernonia amygdalina resulted in the isolation and identification of seven undescribed bisabolane-type sesquiterpenes designated amygdanoids A-G and one known analogue. This is the first report of this type of sesquiterpene from V. amygdalina. Their structures, including the absolute configurations, were elucidated by comprehensive analysis with HRESIMS, 1D and 2D NMR, quantum chemical calculations of NMR and electronic circular dichroism (ECD), modified Mosher's method, and the in situ dimolybdenum CD method. The anti-inflammatory activity of the isolates was evaluated. All the isolated compounds clearly inhibited the production of NO and the expression of the iNOS protein. Secretion of the COX-2 protein was constrained by amygdanoids A-F. Further investigation suggested that amygdanoids E exhibited anti-inflammatory activity by suppressing the expression of iNOS and COX-2 as well as the PI3K/AKT/NF-κB signaling pathway.
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