Reaction of Fe3(CO)12 with octreotide—chemical, electrochemical and biological investigations

In search for peptidic [FeFe] hydrogenase mimics, the cyclic disulfide Sandostatin® (octreotide) was allowed to react with Fe3(CO)12. An octreotide-Fe2(CO)6 complex was isolated and characterized spectroscopically as well as by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H+ to H2. It is suggested by radioligand binding assays that the complex retains much of the binding affinity for the somatostatin hsst1-5 receptors of octreotide.