284P Gut microbiota mediates the protective effects of resveratrol against the intestinal barrier dysfunction in non-alcoholic steatohepatitis induced by high-fat diet

Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing globally. We investigate the ameliorative effects of resveratrol (RSV) in a high fat diet (HFD)-induced NASH rat model, focusing on the gut microbiota and cannabinoid receptor type 1 (CB1) in the maintenance of gut barrier integrity.