A facile approach toward γ-branched amines via copper-catalyzed 1,3-aminoalkynylation and aminobromination of arylcyclopropanes

A copper-catalyzed 1,3-aminoalkynylation or 1,3-aminobromination of arylcyclopropane with N-fluorobenzenesulfonimide (NFSI) and trimethoxy[(trimethylsilyl)ethynyl]silane or LiBr have been successfully developed. Through this strategy, a wide range of γ-alkylnyl-/γ-bromino-γ-branched amine derivatives were efficiently synthesized in good yields under mild conditions.