Copper-Catalyzed Carbonylation Reactions: A Personal Account

Abstract Carbonylation reactions have been widely used to construct carbonyl-containing molecules or carbon enhancement reactions, which are mostly catalyzed by noble metals (Pd, Rh, Ru, Ir). In this review, we introduce the copper-catalyzed carbonylation reactions that have been developed in our group. Diverse reactions have been developed using various substrates, including the carbonylation of C–H activated alkanes, the difunctionalization of unsaturated C–C bonds, and the carbonylation of alkyl halides via the radical pathway. 1 Introduction 2 Cu-Catalyzed Carbonylation of C(sp 3)–H Bonds 3 Cu-Catalyzed Carbonylative Difunctionalization of Unsaturated Bonds 4 Cu–X (H or B) Mediated Acylation of Unsaturated Bonds with Electrophiles 5 Cu–X (H or B) Mediated Carbonylation of Unsaturated Bonds 6 Cu-Catalyzed Carbonylation of Alkyl Halides 7 Other Types of Copper-Catalyzed Carbonylation Reactions 8 Conclusion and Outlook