结直肠癌
医学
免疫系统
癌症
情感(语言学)
肿瘤科
内科学
生物信息学
老年学
免疫学
心理学
生物
沟通
作者
Oana‐Maria Thoma,Markus F. Neurath,Maximilian J. Waldner
出处
期刊:Cancers
[Multidisciplinary Digital Publishing Institute]
日期:2021-12-11
卷期号:13 (24): 6227-6227
被引量:9
标识
DOI:10.3390/cancers13246227
摘要
Colorectal cancer (CRC) continues to be one of the most frequently diagnosed types of cancers in the world. CRC is considered to affect mostly elderly patients, and the number of diagnosed cases increases with age. Even though general screening improves outcomes, the overall survival and recurrence-free CRC rates in aged individuals are highly dependent on their history of comorbidities. Furthermore, aging is also known to alter the immune system, and especially the adaptive immune T cells. Many studies have emphasized the importance of T cell responses to CRC. Therefore, understanding how age-related changes affect the outcome in CRC patients is crucial. This review focuses on what is so far known about age-related T cell dysfunction in elderly patients with colorectal cancer and how aged T cells can mediate its development. Last, this study describes the advances in basic animal models that have potential to be used to elucidate the role of aged T cells in CRC.
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