转录组
转移
癌症
原发性肿瘤
生物
癌症研究
基因
原发性癌症
癌细胞
病理
基因表达
医学
遗传学
作者
Neel Sanghvi,Camilo Calvo-Alcañiz,Padma Sheila Rajagopal,Stefano Scalera,Valeria Canu,Sanju Sinha,Fiorella Schischlik,Kun Wang,Sanna Madan,Eldad D. Shulman,Antonios Papanicolau‐Sengos,Giovanni Blandino,Eytan Ruppin,Nishanth Ulhas Nair
标识
DOI:10.1101/2023.10.30.564810
摘要
Metastasis is a leading cause of cancer-related deaths, yet understanding how metastatic tumors adapt from their origin to target tissues is challenging. To address this, we assessed whether primary and metastatic tumors resemble their tissue of origin or target tissue in terms of gene expression. We analyzed gene expression profiles from various cancer types, including single-cell and bulk RNA-seq data, in both paired and unpaired primary and metastatic patient cohorts. We quantified the transcriptomic distances between tumor samples and their normal tissues, revealing that primary tumors are more similar to their tissue of origin, while metastases shift towards the target tissue. Pathway-level analysis highlighted critical transcriptomic changes during metastasis. Notably, primary cancers exhibited higher activity in cancer hallmarks, including Activating Invasion and Metastasis , compared to metastatic cancers. This comprehensive landscape analysis provides insight into how cancer tumors adapt to their metastatic environments, providing a transcriptome-wide view of the processes involved.
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