纤维连接蛋白
层粘连蛋白
细胞外基质
脂肪组织
基底膜
化学
细胞生物学
脂肪细胞
佩莱肯
白色脂肪组织
结缔组织
基底层
蛋白多糖
生物
生物化学
解剖
超微结构
遗传学
作者
C Pierleoni,F Verdenelli,Mario Castellucci,Saverio Cinti
出处
期刊:PubMed
日期:1998-01-01
卷期号:42 (3): 183-8
被引量:27
摘要
Adipose tissue is a type of connective tissue whose extracellular matrix (ECM) components are poorly characterized in vivo. Several in vitro studies have suggested a regulatory role for the ECM molecules during adipocyte differentiation. Since no data are available concerning the in vivo expression of the main ECM components such as fibronectin, collagen IV, laminin and heparan sulfate proteoglycan in the adipose tissue, we investigated the presence of these molecules by immunohistochemistry. We show that fibronectin isoforms are not expressed in fully differentiated subcutaneous adipocytes whereas collagen IV, laminin and heparan sulfate are detectable around single adipocytes, i.e. in the region corresponding to the basement membrane. These data are supported by previous in vitro studies showing a strong decrease of fibronectin synthesis during adipocyte development whereas basement membrane molecules seem to increase during adipocyte differentiation.
科研通智能强力驱动
Strongly Powered by AbleSci AI