噬菌体疗法
光谱学
纳米技术
拉曼光谱
分子光谱学
表征(材料科学)
红外光谱学
抗生素耐药性
表面增强拉曼光谱
计算生物学
噬菌体
材料科学
化学
微生物学
生物
物理
抗生素
光学
拉曼散射
生物化学
大肠杆菌
有机化学
量子力学
基因
作者
Magdalena Giergiel,Thulya Chakkumpulakkal Puthan Veettil,Astrea Rossetti,Kamila Kochan
摘要
Bacteriophages are emerging as a promising alternative in combating antibiotic-resistant bacteria amidst the escalating global antimicrobial resistance crisis. Recently, there has been a notable resurgence of interest in phages, prompting extensive research into their therapeutic potential. Beyond conventional microbiology and virology techniques, such as genomics and proteomics, novel phenotypic and chemical characterization methods are being explored. Among these, there is a growing interest in vibrational spectroscopy, especially in advanced modalities such as surface-enhanced Raman spectroscopy (SERS), tip-enhanced Raman spectroscopy (TERS), and atomic force microscopy-infrared spectroscopy (AFM-IR), which offer improved sensitivity and spatial resolution. This review explores the spectrum of uses of vibrational spectroscopy for bacteriophages, including its role in diagnostics, biosensing, phage detection, assistance in phage-based therapy, and advancing basic research.
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