Transcriptomic Analysis Reveals Bovine Herpesvirus 1 Infection Regulates Innate Immune Response Resulted in Restricted Viral Replication in Neuronal Cells

Bovine herpesvirus 1 (BoHV-1) is a major pathogen that affects the global bovine population, primarily inducing respiratory and reproductive disorders. Its ability to establish latent infections in neuronal cells and to reactivate under certain conditions poses a continual threat to uninfected hosts. In this study, we aimed to analyze the replication characteristics of BoHV-1 in neuronal cells, as well as the effects of viral replication on host cell immunity and physiology.