代谢组学
转录组
新陈代谢
碳水化合物代谢
脂质代谢
生物
糖酵解
脂肪酸代谢
嘌呤代谢
生物化学
代谢途径
核酸代谢
谷胱甘肽
毛囊
次生代谢
细胞生物学
基因表达
生物信息学
基因
生物合成
核糖核酸
酶
作者
Xuewen Wang,Cai Chen,Qiao Liang,Meng Xia,Lihua Lai,Xia Wu,Xiaoyun Jiang,Hao Cheng,Yinjing Song,Qiang Zhou
标识
DOI:10.3389/fmolb.2022.781619
摘要
Psychological stress plays an important role in hair loss, but the underlying mechanisms are not well-understood, and the effective therapies available to regrow hair are rare. In this study, we established a chronic restraint stress (CRS)-induced hair growth inhibition mouse model and performed a comprehensive analysis of metabolomics and transcriptomics. Metabolomics data analysis showed that the primary and secondary metabolic pathways, such as carbohydrate metabolism, amino acid metabolism, and lipid metabolism were significantly altered in skin tissue of CRS group. Transcriptomics analysis also showed significant changes of genes expression profiles involved in regulation of metabolic processes including arachidonic acid metabolism, glutathione metabolism, glycolysis gluconeogenesis, nicotinate and nicotinamide metabolism, purine metabolism, retinol metabolism and cholesterol metabolism. Furthermore, RNA-Seq analyses also found that numerous genes associated with metabolism were significantly changed, such as Hk-1, in CRS-induced hair growth inhibition. Overall, our study supplied new insights into the hair growth inhibition induced by CRS from the perspective of integrated metabolomics and transcriptomics analyses.
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