肿瘤微环境
癌症研究
光动力疗法
免疫疗法
免疫系统
上睑下垂
胰腺癌
细胞毒性T细胞
癌症免疫疗法
CD8型
癌症
化学
医学
免疫学
生物
炎症
炎症体
内科学
生物化学
有机化学
体外
作者
Meng Wang,Min Wu,Xingang Liu,Shiyi Shao,Junmin Huang,Bin Liu,Tingbo Liang
标识
DOI:10.1002/advs.202202914
摘要
Immunotherapy, the most promising strategy of cancer treatment, has achieved promising outcomes, but its clinical efficacy in pancreatic cancer is limited mainly due to the complicated tumor immunosuppressive microenvironment. As a highly inflammatory form of immunogenic cell death (ICD), pyroptosis provides a great opportunity to alleviate immunosuppression and promote systemic immune responses in solid tumors. Herein, membrane-targeted photosensitizer TBD-3C with aggregation-induced emission (AIE) feature to trigger pyroptosis-aroused cancer immunotherapy via photodynamic therapy (PDT) is applied. The results reveal that pyroptotic cells induced by TBD-3C could stimulate M1-polarization of macrophages, cause maturation of dendritic cells (DCs), and activation of CD8+ cytotoxic T-lymphocytes (CTLs). Pyroptosis-aroused immunological responses could convert immunosuppressive "cold" tumor microenvironment (TME) to immunogenic "hot" TME, which not only inhibits primary pancreatic cancer growth but also attacks the distant tumor. This work establishes a platform with high biocompatibility for light-controlled antitumor immunity and solid tumor immunotherapy aroused by cell pyroptosis.
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