细胞生物学
分泌物
内体
微泡
入侵足纲
生物
胞外囊泡
运动性
内质网
化学
癌细胞
细胞内
生物化学
癌症
小RNA
基因
遗传学
作者
Fang Zhen,Yue Sun,Hongyi Wang,Бо Лю,Xiao Liang,Li Wang,Xiaogang Wang,Jing Hu
标识
DOI:10.1002/advs.202405731
摘要
Abstract Tumor‐derived extracellular vesicles (EVs) are potential biomarkers for tumors, but their reliable molecular targets have not been identified. The previous study confirms that ubiquitin‐specific protease 22 (USP22) promotes lung adenocarcinoma (LUAD) metastasis in vivo and in vitro. Moreover, USP22 regulates endocytosis of tumor cells and localizes to late endosomes. However, the role of USP22 in the secretion of tumor cell‐derived EVs remains unknown. In this study, it demonstrates that USP22 increases the secretion of tumor cell‐derived EVs and accelerates their migration and invasion, invadopodia formation, and angiogenesis via EV transfer. USP22 enhances EV secretion by upregulating myosin IB (MYO1B). This study further discovers that USP22 activated the SRC signaling pathway by upregulating the molecule KDEL endoplasmic reticulum protein retention receptor 1 (KDELR1), thereby contributing to LUAD cell progression. The study provides novel insights into the role of USP22 in EV secretion and cell motility regulation in LUAD.
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