Clinical Observation of Neoadjuvant Artery Chemotherapy with Carboplatin and Intratumoral Injection of Lifein for Advanced Cervical Cancer

Objective To investigate the clinical efficacy of neoadjuvant artery chemotherapy with carboplatin and intratumoral injection of Lifein for advanced cervical cancer. Methods 168 cases of advanced cervical cancer patients were selected and randomly divided into the observation group and the control group,with 84 cases in each group. The control group were treated with neoadjuvant chemotherapy with carboplatin,the observation group were treated with intratumoral injection of Lifein on the basis of the control group,the clinical efficacy of the 2 groups were compared. Results The total effective rates of stage ⅡB to Ⅳ a patients of the observation group and the control group were 84. 5% and 64. 3%,the difference between the 2 groups was statistically significant( P 0. 05). The incidence rates of bone marrow suppression,gastrointestinal reactions,alopecia and neurotoxicity of the observation group were lower than those of the control group,the incidence rate of fever of the observation group was higher than that of the control group. The operation resection rates of the observation group and the control group were 97. 6% and 90. 5%,respectively,the difference between the 2 groups was statistically significant( P 0. 05). The tumour transfer rates of the observation group and the control group was 1. 2% and 8. 3%,respectively,the difference was statistically significant( P 0. 05). The 5-year survival rates of ⅡB stage patients of the observation group and the control group were 87% and 75%,there had no statistical difference( P 0. 05); the 5-year survival rates of Ⅲ stage patients of the observation group and the control group were 75. 8% and 66. 7%,there had no statistical difference( P 0. 05). 1 Ⅳa stage patient in the observation group survived 5. 2 years,while no Ⅳa stage patients in the control group survived more than 4 years. Conclusion Neoadjuvant artery chemotherapy with carboplatin and intratumoral injection of Lifein for advanced cervical cancer can significantly improve chemotherapy effective rate and operation resection rate,reduce adverse reactions and tumor metastasis rate,and improve long- term survival rate. It is worthy of clinical application.