非洲猪瘟病毒
生物
病毒学
病毒复制
DNA病毒
病毒
核心
病毒进入
基因组
细胞生物学
遗传学
基因
作者
Margarida Simões,Ferdinando B. Freitas,Alexandre Leitão,Carlos Martins,Fernando Ferreira
出处
期刊:Virus Research
[Elsevier]
日期:2019-09-01
卷期号:270: 197667-197667
被引量:38
标识
DOI:10.1016/j.virusres.2019.197667
摘要
African swine fever (ASF) is currently matter for major concerns in global swine industry as it is highly contagious and causes acute fatal haemorrhagic fever in domestic pigs and wild boar. The absence of effective vaccines and treatments pushes ASF control to relay on strict sanitary and stamping out measures with costly socio-economic impacts. The current epidemic scenario of fast spreading throughout Asiatic countries impels further studies on prevention and combat strategies against ASF. Herein we review knowledge on African Swine Fever Virus (ASFV) interactions with the host cell nucleus and on the functional properties of different viral DNA-replication related proteins. This entails, the confirmation of an intranuclear viral DNA replication phase, the characterization of cellular DNA damage responses (DDR), the subnuclear compartments disruption due to viral modulation, and the unravelling of the biological role of several viral proteins (A104R, I215 L, P1192R, QP509 L and Q706 L), so to contribute to underpin rational strategies for vaccine candidates development.
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