癌症
转移
癌细胞
基质金属蛋白酶
免疫印迹
MTT法
癌症研究
庆大霉素保护试验
化疗
医学
肿瘤科
生物
内科学
细胞生长
生物化学
基因
作者
Jin Xu,Jianbo Wu,Chuankang Tang
出处
期刊:Cellular and Molecular Biology
日期:2020-04-20
卷期号:66 (1): 27-31
被引量:3
标识
DOI:10.14715/cmb/2019.66.1.4
摘要
Gastric cancer (GC) is one of the most common fatal cancers among gastrointestinal malignancies. At present, the treatment of gastric cancer involves a combination of surgery and chemotherapy. Isofebrifugine (IFE) is an alkaloid with many biological properties. In this study, results from MTT, scratch and invasion assays showed that IFE significantly inhibited the proliferation, migration and invasion of SGC7901 gastric cancer cells. Through RT-PCR and Western blot experiments, it was revealed that IFE significantly inhibited the mRNA and protein expressions of MMP-2, MMP-9 and SDF-1 which are closely related to cancer invasion and metastasis. Thus, IFE possesses anti-gastric cancer properties.
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