Low Risk of Periprosthetic Joint Infection After Aseptic Revision Total Knee Arthroplasty with Intraosseous Vancomycin

Aseptic revisions are the most common reason for revision total knee arthroplasty (rTKA). Previous literature reports early periprosthetic joint infection (PJI) rates after aseptic rTKA to range from 3 to 9.4%. Intraosseous regional administration (IORA) of vancomycin has previously been shown to produce high local tissue concentrations in primary and revision TKA. However, no data exists on the effect of prophylactic intraosseous (IO) vancomycin on early PJI rates in the setting of aseptic rTKA. The aim of this study was to determine: (1) what is the rate of early PJI during the first year after surgery in aseptic rTKA performed with IO vancomycin; and (2) how does this compare to previously published PJI rates after rTKA.