神经科学
神经元
生物
神经系统
秀丽隐杆线虫
钙显像
神经细胞
细胞神经科学
生物神经网络
细胞融合
神经退行性变
神经网络
中间神经元
运动神经元
细胞
生物神经元模型
索马
脊髓
疾病
抑制性突触后电位
钙
医学
化学
遗传学
有机化学
病理
基因
作者
Rosina Giordano-Santini,Eva Kaulich,Kate M. Galbraith,Fiona K. Ritchie,Wei Wang,Zhaoyu Li,Massimo A. Hilliard
标识
DOI:10.1073/pnas.1919063117
摘要
Significance Ramón y Cajal’s neuron doctrine, which states that neurons are individual cells that do not share any membrane or cytoplasmic continuity between them, has underpinned our view of modern neuroscience. However, there is considerable evidence that fusogens, specialized proteins essential and sufficient for the fusion of cells in other tissues, are expressed in the nervous system of several species in response to viral infection, stress conditions, and neurological disease. By manipulating the expression of fusogens in the chemosensory neurons of Caenorhabditis elegans , our results provide conclusive evidence that deregulation of fusogen expression causes neuronal fusion and can have deleterious effects on neural circuitry and behavioral outputs, revealing a possible novel underlying cause of neurological disorders.
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