效应器
抑制器
功能(生物学)
细胞周期
细胞生物学
癌症
激酶
生物
癌症研究
细胞周期检查点
癌细胞
细胞周期蛋白依赖激酶
神经科学
遗传学
作者
Tarek Abbas,Anindya Dutta
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2009-05-14
卷期号:9 (6): 400-414
被引量:2444
摘要
One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals. This Review focuses on recent advances in our understanding of the regulation of p21 and its biological functions with emphasis on its p53-independent tumour suppressor activities and paradoxical tumour-promoting activities, and their implications in cancer.
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