自愈水凝胶
苯胺
肿胀 的
戊二醛
化学工程
高分子化学
材料科学
壳聚糖
药物输送
化学
纳米技术
有机化学
复合材料
工程类
作者
Baolin Guo,Anna Finne‐Wistrand,Ann‐Christine Albertsson
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2011-05-24
卷期号:12 (7): 2601-2609
被引量:158
摘要
Degradable and electrically conductive polysaccharide hydrogels (DECPHs) have been synthesized by functionalizing polysaccharide with conductive aniline oligomers. DECPHs based on chitosan (CS), aniline tetramer (AT), and glutaraldehyde were obtained by a facile one-pot reaction by using the amine group of CS and AT under mild conditions, which avoids the multistep reactions and tedious purification involved in the synthesis of degradable conductive hydrogels in our previous work. Interestingly, these one-pot hydrogels possess good film-forming properties, electrical conductivity, and a pH-sensitive swelling behavior. The chemical structure and morphology before and after swelling of the hydrogels were verified by FT-IR, NMR, and SEM. The conductivity of the hydrogels was tuned by adjusting the content of AT. The swelling ratio of the hydrogels was altered by the content of tetraaniline and cross-linker. The hydrogels underwent slow degradation in a buffer solution. The hydrogels obtained by this facile approach provide new possibilities in biomedical applications, for example, biodegradable conductive hydrogels, films, and scaffolds for cardiovascular tissue engineering and controlled drug delivery.
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