黑色素瘤
胶质母细胞瘤
医学
胶质瘤
信任
癌症
联想(心理学)
肿瘤科
癌症研究
心理学
内科学
计算机科学
机器学习
心理治疗师
作者
Kei Shing Oh,Meera Mahalingam
出处
期刊:Advances in Anatomic Pathology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-01-10
卷期号:30 (5): 320-335
标识
DOI:10.1097/pap.0000000000000393
摘要
Recently, we came across a patient with malignant melanoma and primary glioblastoma. Given this, we parsed the literature to ascertain the relationship, if any, between these 2 malignancies. We begin with a brief overview of melanoma and glioma in isolation followed by a chronologic overview of case reports and epidemiologic studies documenting both neoplasms. This is followed by studies detailing genetic abnormalities common to both malignancies with a view to identifying unifying genetic targets for therapeutic strategies as well as to explore the possibility of a putative association and an inherited cancer susceptibility trait. From a scientific perspective, we believe we have provided evidence favoring an association between melanoma and glioma. Future studies that include documentation of additional cases, as well as a detailed molecular analyses, will lend credence to our hypothesis that the co-occurrence of these 2 conditions is likely not serendipitous.
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