某种肠道细菌
粘液
阿克曼西亚
微生物学
肠细胞
秋葵
炎症
化学
生物
生物化学
免疫学
肠道菌群
生态学
小肠
发酵
农学
乳酸菌
作者
Yaozheng Wang,Chengxi Li,Jianping Li,Shu Zhang,Qinyu Zhang,Jin‐Ao Duan,Jianming Guo
标识
DOI:10.1016/j.apsb.2024.06.002
摘要
The intestinal mucus barrier is an important line of defense against gut pathogens. Damage to this barrier brings bacteria into close contact with the epithelium, leading to intestinal inflammation. Therefore, its restoration is a promising strategy for alleviating intestinal inflammation. This study showed that Abelmoschus manihot polysaccharide (AMP) fortifies the intestinal mucus barrier by increasing mucus production, which plays a crucial role in the AMP-mediated amelioration of colitis. IL-10-deficient mouse models demonstrated that the effect of AMP on mucus production is dependent on IL-10. Moreover, bacterial depletion and replenishment confirmed that the effects of AMP on IL-10 secretion and mucus production were mediated by Akkermansia muciniphila. These findings suggest that plant polysaccharides fortify the intestinal mucus barrier by maintaining homeostasis in the gut microbiota. This demonstrates that targeting mucus barrier is a promising strategy for treating intestinal inflammation.
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