Late-Stage Modification of Peptides with Maleimides through Palladium-Catalyzed β-C(sp3)–H Alkylation

Transition-metal-catalyzed C-H activation has proven to be a powerful tool for the late-stage modification of peptides. We herein report a method for site-selective alkylation of peptides with maleimides through Pd-catalyzed β-C(sp