巨噬细胞移动抑制因子
生物
癌症研究
白血病
癌基因
发病机制
炎症
免疫学
癌症
白血病抑制因子
巨噬细胞
细胞
细胞生物学
细胞因子
作者
Yaosheng Luo,Xiao Wang,Jie Shen,Jie Yao
标识
DOI:10.3892/ijo.2021.5242
摘要
Leukemia is a group of malignant diseases of clonal hematopoietic stem‑progenitor cells and its pathological mechanisms remain to be elucidated. Genetic and epigenetic abnormalities, as well as microenvironmental factors, including cytokines, serve critical roles in leukaemogenesis. Macrophage migration inhibitory factor (MIF) has been presented as one of the key regulators in tumorigenesis, angiogenesis and tumor metastasis. This article focuses on the functional role of MIF and its pathway in cancer, particularly in leukemia. MIF/CD74 interaction serves prominent roles in tumor cell survival, such as upregulating BCL‑2 and CD84 expression, and activating receptor‑type tyrosine phosphatase ζ. Furthermore, MIF upregulation forms a pro‑tumor microenvironment in response to hypoxia‑induced factors and promotes pro‑inflammatory cytokine production. Additionally, polymorphisms of the MIF promoter sequence are associated with leukemia development. MIF signal‑targeted early clinical trials show positive results. Overall, these efforts provide a promising means for intervention in leukemia.
科研通智能强力驱动
Strongly Powered by AbleSci AI