Measurement properties of the patient global assessment numerical rating scale in moderate-to-severe psoriasis

医学 银屑病 评定量表 比例(比率) 物理疗法 皮肤病科 统计 数学 地理 地图学
作者
Ning Yu,Chen Peng,Jing Zhou,Jun Gu,Jinhua Xu,Xia Li,Xinling Bi,Hui Deng,Xin Li,Yangfeng Ding,Yuling Shi
出处
期刊:British Journal of Dermatology [Oxford University Press]
卷期号:189 (4): 437-446 被引量:5
标识
DOI:10.1093/bjd/ljad188
摘要

Abstract Background Patient global assessment (PtGA) has been recommended as one of the core domains in psoriasis clinical trials. Among multiple versions of PtGA, the single-question, 11-point PtGA numeric rating scale (NRS) remains to be validated in patients with plaque psoriasis. Objectives To evaluate the psychometric characteristics of an 11-point PtGA NRS for disease severity in patients with moderate-to-severe plaque psoriasis. Methods Data were analysed from 759 patients with moderate-to-severe psoriasis in the Shanghai Psoriasis Effectiveness Evaluation CoHort (SPEECH), a prospective, multicentre and observational registry assessing the comparative effectiveness and safety of biologics (adalimumab, ustekinumab, secukinumab or ixekizumab), conventional systemic therapies (acitretin or methotrexate) and phototherapy. Results The test–retest reliability of the PtGA NRS showed good agreement (intraclass correlation coefficient range 0.79–0.83). No floor or ceiling effects of PtGA NRS were observed. The PtGA NRS was significantly correlated with the Psoriasis Area and Severity Index (PASI), static Physician Global Assessment (sPGA), body surface area, Dermatology Quality of Life Index (DLQI) and Hospital Anxiety and Depression Scale. Relatively large correlations of PtGA NRS with PASI and the DLQI ‘symptoms and feelings’ domain (all correlations ≥ 0.4 except at baseline) supported convergent validity. The presence of psoriatic arthritis or joint symptoms had no significant association with the PtGA NRS. In multivariate regression analyses, the PtGA NRS at baseline was predicted by age, lesion extent, lesion intensity, patients’ symptoms and feelings, and impact on work or school. The PtGA NRS displayed known-groups validity with the PASI, sPGA and DLQI score bands. The PtGA NRS was responsive to change in PASI and DLQI after treatment. Anchor- and distribution-based approaches supported –3 as the minimal important difference for PtGA NRS. An absolute PtGA NRS ≤ 2 during follow-up was concordant with the state of minimal disease activity based on a 90% reduction in PASI (PASI 90) or PASI 90 plus a DLQI of 0/1. Sensitivity analysis using subgroup comparison and multiple imputation model yielded consistent conclusions. Conclusions The PtGA NRS showed good reliability, validity and responsiveness in patients with psoriasis, and was feasible in clinical trials and daily practice.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
hyde完成签到,获得积分10
刚刚
jaypark发布了新的文献求助10
1秒前
1秒前
量子星尘发布了新的文献求助10
2秒前
杜不腾完成签到,获得积分10
2秒前
卢雨生发布了新的文献求助10
2秒前
3秒前
Twelve发布了新的文献求助10
3秒前
wenbo发布了新的文献求助10
3秒前
完美世界应助子云采纳,获得10
4秒前
扭一扭的奥利奥完成签到,获得积分10
4秒前
4秒前
望北完成签到,获得积分20
5秒前
5秒前
5秒前
5秒前
gao发布了新的文献求助10
5秒前
许阳发布了新的文献求助10
6秒前
Ava应助立里采纳,获得10
6秒前
sugarmei完成签到,获得积分10
7秒前
7秒前
英姑应助再睡亿分钟采纳,获得10
7秒前
xiaoyao完成签到,获得积分10
8秒前
8秒前
燕子发布了新的文献求助10
9秒前
猪猪hero发布了新的文献求助10
9秒前
欣慰碧琴完成签到,获得积分10
9秒前
卢雨生完成签到,获得积分20
9秒前
9秒前
xyawl425完成签到,获得积分10
9秒前
10秒前
10秒前
善学以致用应助任性采梦采纳,获得30
10秒前
11秒前
Lucas应助lyw采纳,获得10
11秒前
WILD完成签到 ,获得积分10
11秒前
11秒前
12秒前
12秒前
超帅柚子发布了新的文献求助10
12秒前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
Christian Women in Chinese Society: The Anglican Story 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3961589
求助须知:如何正确求助?哪些是违规求助? 3507917
关于积分的说明 11138698
捐赠科研通 3240341
什么是DOI,文献DOI怎么找? 1790929
邀请新用户注册赠送积分活动 872649
科研通“疑难数据库(出版商)”最低求助积分说明 803306