梅林(蛋白质)
细胞生物学
调节器
磷脂酰肌醇
功能(生物学)
生物
河马信号通路
支架蛋白
细胞骨架
抑制器
化学
信号转导
细胞
生物化学
基因
作者
Pengfei Guo,Bing Li,Wei Dong,Huabin Zhou,Sheng Wang,Ting Su,Christopher Carl,Yonggang Zheng,Yang Hong,Hua Deng,Duojia Pan
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-08-09
卷期号:385 (6709)
标识
DOI:10.1126/science.adf4478
摘要
Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular processes, many biomolecular condensates exist in a solid-like state, and their function and regulation are less understood. We show that the tumor suppressor Merlin, an upstream regulator of the Hippo pathway, localizes to both cell junctions and medial apical cortex in Drosophila epithelia, with the latter forming solid-like condensates that activate Hippo signaling. Merlin condensation required phosphatidylinositol-4-phosphate (PI4P)–mediated plasma membrane targeting and was antagonistically controlled by Pez and cytoskeletal tension through plasma membrane PI4P regulation. The solid-like material properties of Merlin condensates are essential for physiological function and protect the condensates against external perturbations. Collectively, these findings uncover an essential role for solid-like condensates in normal physiology and reveal regulatory mechanisms for their formation and disassembly.
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