癌变
慢性应激
医学
平衡
神经科学
生物信息学
癌症研究
内科学
生物
内分泌学
癌症
作者
Chen Wang,Yumeng Shen,Jiaping Ni,Weiwei Hu,Weiwei Hu
标识
DOI:10.1007/s00018-022-04455-3
摘要
Chronic stress activates the sympathetic nervous system (SNS) and hypothalamic–pituitary–adrenal (HPA) axis to aggravates tumorigenesis and development. Although the importance of SNS and HPA in maintaining homeostasis has already attracted much attention, there is still a lot remained unknown about the molecular mechanisms by which chronic stress influence the occurrence and development of tumor. While some researches have already concluded the mechanisms underlying the effect of chronic stress on tumor, complicated processes of tumor progression resulted in effects of chronic stress on various stages of tumor remains elusive. In this reviews we concluded recent research progresses of chronic stress and its effects on premalignancy, tumorigenesis and tumor development, we comprehensively summarized the molecular mechanisms in between. And we highlight the available treatments and potential therapies for stressed patients with tumor.
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