化学
药效团
偶联反应
催化作用
组合化学
醛
基质(水族馆)
范围(计算机科学)
铜
反应条件
联轴节(管道)
有机化学
立体化学
计算机科学
工程类
程序设计语言
地质学
海洋学
机械工程
作者
Mengting Kou,Ziqiang Wei,Zhen Li,Bin Xu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-11
卷期号:24 (46): 8514-8519
标识
DOI:10.1021/acs.orglett.2c03414
摘要
A copper-catalyzed sulfinyl cross-coupling reaction of sulfinamides with aldehyde-derived N-tosylhydrazones is described. This approach enables facile access for the construction of structurally diverse sulfoxides via novel and efficient S-N/S-C bond interconversions, features broad substrate scope, and accommodates various functional groups as well as pharmacophores. Moreover, the given sulfinyl cross-coupling reaction could be scaled up to the gram scale and carried out in a one-pot fashion directly from aldehydes. The broad utility of produced sulfoxides is demonstrated by further transformations. A preliminary mechanistic investigation was performed, which disclosed possible reaction pathways.
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