化学
立体中心
对映选择合成
卡宾
磷酸
有机化学
四级碳
有机催化
组合化学
立体化学
催化作用
药物化学
作者
Ke-Wei Chen,Su Zhou,Chao Li,Shanliang Dong,Kemiao Hong,Xinfang Xu
摘要
Enantioselective construction of all-carbon quaternary stereocenters has attracted much attention over the past few decades. A variety of catalytic asymmetric methods have been disclosed based on the use of presynthesized complex reagents that impart congested steric hindrance to the reaction center, which generally produce the chiral molecules through forming one C-C bond. The use of readily available reagents that could build two C-C bonds on the same carbonic center with the concomitant assembly of quaternary stereocenters remains challenging. Herein, we disclose a catalytic asymmetric alkyne multifunctionalization reaction using a gold complex and a chiral spiro phosphoric acid (SPA) for synergistic catalysis. In this method, the readily accessible internal alkynes served as the key gold carbene precursors, followed by carbene
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