Protective role of the placental efflux transporter BCRP/ABCG2 in the relationship between prenatal cadmium exposure, placenta weight, and size at birth

胎盘 胎儿 怀孕 出生体重 内分泌学 内科学 泌尿系统 生物 男科 生理学 化学 医学 遗传学 有机化学
作者
Emily S. Barrett,Zorimar Rivera‐Núñez,Kylie Getz,Pamela Ohman‐Strickland,Ranran Zhang,Danielle Kozlosky,Cathleen Doherty,Brian Buckley,Jessica Brunner,Richard K. Miller,Thomas G. O’Connor,Lauren M. Aleksunes
出处
期刊:Environmental Research [Elsevier BV]
卷期号:225: 115597-115597 被引量:7
标识
DOI:10.1016/j.envres.2023.115597
摘要

Placental efflux transporter proteins, such as BCRP, reduce the placental and fetal toxicity of environmental contaminants but have received little attention in perinatal environmental epidemiology. Here, we evaluate the potential protective role of BCRP following prenatal exposure to cadmium, a metal that preferentially accumulates in the placenta and adversely impacts fetal growth. We hypothesized that individuals with a reduced function polymorphism in ABCG2, the gene encoding BCRP, would be most vulnerable to the adverse impacts of prenatal cadmium exposure, notably, smaller placental and fetal size. We measured cadmium in maternal urine samples at each trimester and in term placentas from UPSIDE-ECHO study participants (NY, USA; n = 269). We fit adjusted multivariable linear regression and generalized estimating equation models to examine log-transformed urinary and placental cadmium concentrations in relation to birthweight, birth length, placental weight, and fetoplacental weight ratio (FPR) and stratified models by ABCG2 Q141K (C421A) genotype. Overall 17% of participants expressed the reduced-function ABCG2 C421A variant (AA or AC). Placental cadmium concentrations were inversely associated with placental weight (β = −19.55; 95%CI: −37.06, −2.04) and trended towards higher FPR (β = 0.25; 95%CI: −0.01, 0.52) with stronger associations in 421A variant infants. Notably, higher placental cadmium concentrations in 421A variant infants were associated with reduced placental weight (β = −49.42; 95%CI: 98.87, 0.03), and higher FPR (β = 0.85, 95%CI: 0.18, 1.52), while higher urinary cadmium concentration was associated with longer birth length (β = 0.98; 95%CI: 0.37, 1.59), lower ponderal index (β = −0.09; 95%CI: 0.15, −0.03), and higher FPR (β = 0.42; 95%CI: 0.14, 0.71). Infants with reduced function ABCG2 polymorphisms may be particularly vulnerable to the developmental toxicity of cadmium as well as other xenobiotics that are BCRP substrates. Additional work examining the influence of placental transporters in environmental epidemiology cohorts is warranted.
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