内体
拉布
细胞生物学
生物
溶酶体
GTP酶
生物发生
细胞器
小型GTPase
细胞内
生物化学
信号转导
酶
基因
作者
Lars Langemeyer,Florian Fröhlich,Christian Ungermann
标识
DOI:10.1016/j.tcb.2018.06.007
摘要
Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates the protein and lipid content of the plasma membrane, it participates in the intracellular quality control machinery and is needed for the efficient removal of damaged organelles. This complex network comprises an endosomal membrane system that feeds into the lysosomes, yet also allows recycling of membrane proteins, and probably lipids. Moreover, lysosomal degradation provides the cell with macromolecules for further growth. In this review, we focus primarily on the role of the small Rab GTPases Rab5 and Rab7 as organelle markers and interactors of multiple effectors on endosomes and lysosomes and highlight their role in membrane dynamics, particularly fusion along the endolysosomal pathway.
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