化学
区域选择性
四氟硼酸盐
立体选择性
试剂
有机化学
药物化学
离子液体
催化作用
作者
Ge Gao,Neil Brown,Machiko Minatoya,Keith R. Buszek
标识
DOI:10.1016/j.tetlet.2008.08.076
摘要
We had previously demonstrated the utility of N-vinylpyridinium tetrafluoroborate salts as novel electrophilic coupling partners in Pd(0)-catalyzed Suzuki cross-coupling reactions with aryl and vinyl boronic acids. We now report that these crystalline, air-stable, and non-hygroscopic salts are also useful reagents for the synthesis of symmetrical (2E,4E)-1,6-dioxo-2,4-dienes (diene diones), which in turn are valuable starting materials for the synthesis of various five-membered heterocycles. The optimization of reaction conditions and the scope and limitations of the reductive dimerization are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI