光热治疗
光动力疗法
单线态氧
体内
材料科学
纳米技术
化学
氧气
生物
生物技术
有机化学
作者
Laiping Fang,Qi Meng,Yuan Zhang,Rui Su,Xing Fan,Hong Yang,Yuzhu Hou,Ping’an Ma,Keke Huang,Shouhua Feng
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-11-01
卷期号:17 (21): 21553-21566
被引量:8
标识
DOI:10.1021/acsnano.3c06542
摘要
Designing mitochondria-targeting phototheranostic agents (PTAs), which can simultaneously possess exceptional and balanced type-I photodynamic therapy (PDT) and photothermal therapy (PTT) performance, still remains challenging. Herein, benzene, furan, and thiophene were utilized as π bridges to develop multifunctional PTAs. STB with thiophene as a π bridge, in particular, benefiting from stronger donor–accepter (D–A) interactions, reduced the singlet–triplet energy gap (ΔES1-T1), allowed more free intramolecular rotation, and exhibited outstanding near-infrared (NIR) emission, effective type-I reactive oxygen species (ROS) generation, and relatively high photothermal conversion efficiency (PCE) of 51.9%. In vitro and in vivo experiments demonstrated that positive-charged STB not only can actively target the mitochondria of tumor cells but also displayed strong antitumor effects and excellent in vivo imaging ability. This work subtly established a win–win strategy by π bridge engineering, breaking the barrier of making a balance between ROS generation and photothermal conversion, boosting a dual enhancement of PDT and PTT performance, and stimulating the development of multimodal imaging-guided precise cancer phototherapy.
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