氢甲酰化
马尔科夫尼科夫法则
化学
铑
对映选择合成
催化作用
产量(工程)
有机化学
组合化学
区域选择性
冶金
材料科学
作者
Shuailong Li,Zhuangxing Li,Cai You,Xiuxiu Li,Jiaxin Yang,Hui Lv,Xumu Zhang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-01-14
卷期号:22 (3): 1108-1112
被引量:21
标识
DOI:10.1021/acs.orglett.9b04624
摘要
Rhodium-catalyzed asymmetric anti-Markovnikov hydroformylation of α-substituted acrylates/acrylamides has been developed. By employing the Rh/(S,S)-DTBM-YanPhos complex, a series of β-chiral linear aldehydes were obtained in high yields (up to 94% yield) and high enantioselectivities (up to 96% ee). The utility of this methodology is demonstrated by a gram-scale reaction and a concise synthetic route to chiral γ-butyrolactone.
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