The Pharmacology of Etomidate and Etomidate Derivatives

Harvard Medical School, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts Supported by grant R01-GM087316 from the National Institutes of Health, Bethesda, MD and the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA. The Massachusetts General Hospital has submitted patent applications for some of the etomidate analogues discussed in this review. The author and his laboratory, department, and institution could receive compensation related to the development or sale of this technology. The author is a consultant for and holds an equity interest in Annovation BioPharma Inc. (Cambridge, MA), which has licensed this technology for development. Reprints: Douglas E. Raines, MD, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, GRB444, Boston 02114, MA. E-mail: [email protected]