医学
血小板
主动脉瓣置换术
平均血小板体积
丙二醛
阀门更换
血小板活化
内科学
心脏病学
主动脉瓣
外科
泌尿科
狭窄
氧化应激
作者
Anna Komosa,Bartłomiej Perek,Piotr Rzymski,Barbara Poniedziałek,Marek Grygier,Andrzej Siniawski,Katarzyna Szabatowska,Jolanta M. Siller‐Matula,Marek Jemielity,Marcin Misterski,Maciej Lesiak
出处
期刊:Kardiologia Polska
[Polskie Towarzystwo Kardiologiczne]
日期:2021-04-20
被引量:5
摘要
Intervention-induced platelet hypercoagulability may pose a risk of serious adverse events for patients.This study aimed to assess whether surgical and transcatheter aortic valve replacement (SAVR and TAVR) differ in periprocedural platelet activity.The total number of 24 patients with a mean age (SD) of 71 (13) years who underwent SAVR (n = 12) or TAVR (n = 12) were recruited for the study. The following parameters were evaluated at 4 time-points: (i) platelet indices: total platelet count (PLT), platelet distribution width (PDW) and mean platelet volume (MPV), (ii) MPV/PLT ratio, (iii) platelet level of lipid peroxidation: malondialdehyde (MDA) content and MDA/PLT ratio. Eventually, percentage variations of PLT, PDW, and MPV in relation to the baseline values were determined.MPV/PLT ratio increased significantly after procedures in both groups (P = 0.01 in TAVI and P = 0.01 in SAVR). MDA concentrations were significantly higher when assessed directly post-procedure (P = 0.04) as well as 24 hours later (P = 0.01) in the SAVR and TAVI groups. The indirect parameter of platelet activity indexed for platelet counts (MDA/PLT) was comparable between both groups before and 48 hours after procedures, but was significantly higher in SAVR patients, particularly after 24 hours after interventions (P = 0.04; medians TAVR vs SAVR, respectively).Standard surgical aortic valve replacement is associated with a more pronounced platelet reaction to intervention-induced injury, as compared to the transcatheter-based procedure. The importance of these laboratory findings requires further investigation focused on early and late clinical outcomes.
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