Expression of Odontogenic and Osteogenic Markers in DPSCs and SHED: A Review

牙本质涎磷蛋白 DMP1型 牙髓干细胞 骨钙素 牙本质形成 骨桥蛋白 细胞生物学 细胞外基质 成骨细胞 医学 生物 牙本质 细胞分化 干细胞 成牙本质细胞 碱性磷酸酶 病理 体外 免疫学 遗传学 生物化学 病毒 基因 病毒基质蛋白
作者
Hii Siew Ching,Norhayati Luddin,Ismail Ab Rahman,Thirumulu Ponnuraj Kannan
出处
期刊:Current stem cell research & therapy [Bentham Science]
卷期号:12 (1): 71-79 被引量:148
标识
DOI:10.2174/1574888x11666160815095733
摘要

The odontogenic and osteogenic potential of dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous tooth (SHED) have been shown clearly by various in vitro and in vivo studies. The findings are promising and demonstrated that dental tissue engineering can give a new hope to the individuals suffering from tooth loss and dental diseases. The evaluation of odontogenic and osteogenic differentiation of DPSCs and SHED is commonly carried out by an illustration of the expression of varied related markers. In this review, few commonly used markers such as alkaline phosphatase (ALP), collagen type 1 (Col I), dentin matrix acid phosphoprotein 1 (DMP1), dentin sialophosphoprotein (DSPP), matrix extracellular phosphoglycoprotein (MEPE), osteocalcin (OCN), and osteopontin (OPN). DSPP, DMP1, and MEPE (odontogenic markers), which play an important role during early odontoblastic differentiation and late dentin mineralization, have been highlighted. Osteoblastic proliferation and early/late osteoblastic differentiation can be assessed by estimating the expression of Col I, ALP, OCN and OPN. Despite that, till date, there is no marker which could demonstrate for certain, the differentiation of human DPSCs and SHED towards the odontogenic and osteogenic lineage. This review suggests that SHED are noticeably different from DPSCs and exhibited higher capacity for osteogenic differentiation compared to DPSCs. On the other hand, different expression levels are shown by SHED and DPSCs with regards to the osteoblast markers for osteoblastic differentiation, where, SHED expressed higher levels of ALP, Col I and OCN compared to DPSCs. Keywords: Dental pulp stem cells (DPSCs), differentiation, expression, odontogenic markers, osteoblast markers, stem cells from human exfoliated deciduous tooth (SHED).
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