生物
多细胞生物
寄主(生物学)
计算生物学
疾病
能量代谢
免疫
新陈代谢
代谢组学
医学
免疫系统
细菌
微生物代谢
生态学
遗传学
基因
生物信息学
生物化学
内分泌学
病理
作者
Justin L. McCarville,Grischa Y. Chen,Víctor D. Cuevas,Katia Troha,Janelle S. Ayres
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2020-04-26
卷期号:38 (1): 147-170
被引量:165
标识
DOI:10.1146/annurev-immunol-071219-125715
摘要
Metabolism is one of the strongest drivers of interkingdom interactions—including those between microorganisms and their multicellular hosts. Traditionally thought to fuel energy requirements and provide building blocks for biosynthetic pathways, metabolism is now appreciated for its role in providing metabolites, small-molecule intermediates generated from metabolic processes, to perform various regulatory functions to mediate symbiotic relationships between microbes and their hosts. Here, we review recent advances in our mechanistic understanding of how microbiota-derived metabolites orchestrate and support physiological responses in the host, including immunity, inflammation, defense against infections, and metabolism. Understanding how microbes metabolically communicate with their hosts will provide us an opportunity to better describe how a host interacts with all microbes—beneficial, pathogenic, and commensal—and an opportunity to discover new ways to treat microbial-driven diseases.
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