医学
胱硫醚γ裂解酶
胱硫醚β合酶
疾病
一氧化氮
心肌梗塞
酶
冠状动脉疾病
心力衰竭
生物信息学
药理学
生物化学
内科学
生物
半胱氨酸
作者
Gopi K. Kolluru,Rodney E. Shackelford,Xinggui Shen,Paari Dominic,Christopher G. Kevil
标识
DOI:10.1038/s41569-022-00741-6
摘要
Hydrogen sulfide (H2S) has emerged as a gaseous signalling molecule with crucial implications for cardiovascular health. H2S is involved in many biological functions, including interactions with nitric oxide, activation of molecular signalling cascades, post-translational modifications and redox regulation. Various preclinical and clinical studies have shown that H2S and its synthesizing enzymes - cystathionine γ-lyase, cystathionine β-synthase and 3-mercaptosulfotransferase - can protect against cardiovascular pathologies, including arrhythmias, atherosclerosis, heart failure, myocardial infarction and ischaemia-reperfusion injury. The bioavailability of H2S and its metabolites, such as hydropersulfides and polysulfides, is substantially reduced in cardiovascular disease and has been associated with single-nucleotide polymorphisms in H2S synthesis enzymes. In this Review, we highlight the role of H2S, its synthesizing enzymes and metabolites, their roles in the cardiovascular system, and their involvement in cardiovascular disease and associated pathologies. We also discuss the latest clinical findings from the field and outline areas for future study.
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