立体化学
细胞毒性
体外
化学
菊科
二萜
IC50型
细胞培养
传统医学
生物
植物
生物化学
医学
遗传学
作者
Yuanyuan Zhang,Heng Jiang,Miao Liu,Kun Hu,Weiguang Wang,Xue Du,Xiaonian Li,Jian‐Xin Pu,Han‐Dong Sun
标识
DOI:10.1016/j.phytochem.2017.08.009
摘要
Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A–G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC50 values ranging from 0.5 to 6.5 μM; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
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