Aqueous Electrochemical Synthesis of 5-Trifluoromethyluracil in Batch and Continuous Flow

Without the use of chemical oxidants and metal catalysts, an aqueous electrochemical synthesis of 5-trifluoromethyluracil in batch and continuous flow was reported. The green and economically friendly approach employing commercially available CF3SO2Na as a CF3 source and cheap (NH4)2SO4 as a supporting electrolyte afforded the 5-trifluoromethyluracil in 10 g scale in batch electrolysis. The continuous flow-electrolysis technique was employed to further facilitate the scale-up synthesis of 5-trifluoromethyluracil.