TLR2型
免疫学
皮肤利什曼病
TLR4型
免疫系统
Toll样受体
先天免疫系统
生物
寄生虫负荷
白细胞介素10
模式识别受体
肿瘤坏死因子α
炎症
利什曼病
受体
医学
生物化学
作者
Pedro Paulo Carneiro,Andreza S. Dórea,Walker Nonato Ferreira Oliveira,Luiz Henrique Guimarães,Cláudia Brodskyn,Edgar M. Carvalho,Olı́via Bacellar
标识
DOI:10.3389/fimmu.2021.706510
摘要
Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a pronounced inflammatory response associated with ulcer development. Monocytes/macrophages, the main cells harboring parasites, are largely responsible for parasite control. Toll-like receptor (TLR) signaling leads to the transcription of inflammatory mediators, such as IL-1β and TNF during innate immune response. TLR antagonists have been used in the treatment of inflammatory disease. The neutralization of these receptors may attenuate an exacerbated inflammatory response. We evaluated the ability of TLR2 and TLR4 antagonists to modulate host immune response in L. braziliensis-infected monocytes and cells from CL patient skin lesions. Following TLR2 and TLR4 neutralization, decreased numbers of infected cells and internalized parasites were detected in CL patient monocytes. In addition, reductions in oxidative burst, IL-1β, TNF and CXCL9 production were observed. TNF production by cells from CL lesions also decreased after TLR2 and TLR4 neutralization. The attenuation of host inflammatory response after neutralizing these receptors suggests the potential of TLR antagonists as immunomodulators in association with antimonial therapy in human cutaneous leishmaniasis.
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