The environmental distribution and toxicity of short-chain chlorinated paraffins and underlying mechanisms: Implications for further toxicological investigation

Short-chain chlorinated paraffin (SCCP) pollution has become a global threat. Much attention has been paid to their environmental occurrence and toxicity. In this review, we summarized the wide distribution of SCCPs in various environmental matrices and biota, including human beings. Toxicokinetics and the toxicities of SCCPs, including lethality, hepatotoxicity, developmental toxicity, carcinogenicity, endocrine- and metabolism-disrupting effects, and immunomodulatory effects have been considered. The mechanisms of SCCP toxicity are mainly related to oxidative stress, metabolic disturbance, endocrine disruption and binding to biomacromolecules. In the future, further studies of SCCPs should focus on searching for their novel toxicity targets, and uncovering their toxic effects using transcriptomics, proteomics, metabolomics, and mutigenerational toxicity.